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KMID : 0525719990040010015
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Journal of Chitin and Chitosan
1999 Volume.4 No. 1 p.15 ~ p.18
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Inhibitory Effect of Chitosan on the Milk Transfer of Radiostrontium from Contaminated Mice to their Sucklers
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김영호/Kim YH
범희승/김광윤/김희경/김지열/Bom HS/Kim KY/Kim HK/Kim JY
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Abstract
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Since bone metabolism is very active in littles, it has been supposed that radiostrontium supplied from mother`s milk will contaminate littles. The purpose of this study was to evaluate whether chitosan could block the transfer of radiostrontium from mother`s milk to littles. ICR strain female mice (8~ 10 weeks of age, body weight 25~35 g) and littles (one week of age, body weight 1 ~5 g) were used in this experiment. Radiostrontium (85SrCl2) was diluted to 0.005 y Ci/B.W(g), and the solution was administered to mother orally using a orogastric tube. The radioactivities in littles were measured with a gamma counter. The radiostrontium transfer from mother to little by maternal increased with the time. Chitosan significantly reduced the milk transfer of radiostrontium to littles (p <0.05). Therefore, we concluded that chitosan could block transfer of radiostrontium through mother`s milk to littles in mice.
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KEYWORD
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